Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease
Identifieur interne : 001091 ( Main/Exploration ); précédent : 001090; suivant : 001092Comparison of brain MRI and 18F‐FDG PET in the differential diagnosis of multiple system atrophy from Parkinson's disease
Auteurs : Kyum-Yil Kwon [Corée du Sud] ; Choong G. Choi [Corée du Sud] ; Jae S. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud] ; Sun J. Chung [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
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Abstract
To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21714
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Choi</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2352">2352</biblScope><biblScope unit="page" to="2358">2358</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6C19A58595B60C7ABE9642D438D05CFF277BDA8E</idno><idno type="DOI">10.1002/mds.21714</idno><idno type="ArticleID">MDS21714</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F‐FDG PET</term><term>MRI</term><term>Parkinson's disease</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P and 12 MSA‐C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA‐P, MSA‐C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F‐FDG PET analysis, and 84.3% for SPM‐supported analysis of 18F‐FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F‐FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F‐FDG PET are diagnostically useful in differentiating MSA (MSA‐P and MSA‐C) from PD, and indicate that 18F‐FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kwon, Kyum Il" sort="Kwon, Kyum Il" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name></noRegion><name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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